Ki Summary

Reaction Details

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Target

Regulator of G-protein signaling 4

Ligand

BDBM34524

Substrate/Competitor

n/a

Meas. Tech.

Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao for SAR compounds

EC50

30000±n/a nM

Citation

PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao for SAR compounds PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Regulator of G-protein signaling 4

Name:

Regulator of G-protein signaling 4

Synonyms:

RGP4 | RGS4 | RGS4_HUMAN | Regulator of G-protein signaling 4 (RGS4)

Type:

Enzyme

Mol. Mass.:

23263.51

Organism:

Homo sapiens (Human)

Description:

P49798

Residue:

205

Sequence:

MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWA
ESLENLISHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFIS
VQATKEVNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNP
SSCGAEKQKGAKSSADCASLVPQCA

BDBM34524

n/a

Name

BDBM34524

Synonyms:

2-[2-keto-2-[3-methyl-4-(m-tolyl)piperazino]ethyl]-4,6-dimethyl-isothiazolo[5,4-b]pyridin-3-one | 4,6-dimethyl-2-[2-[3-methyl-4-(3-methylphenyl)-1-piperazinyl]-2-oxoethyl]-3-isothiazolo[5,4-b]pyridinone | 4,6-dimethyl-2-[2-[3-methyl-4-(3-methylphenyl)piperazin-1-yl]-2-oxidanylidene-ethyl]-[1,2]thiazolo[5,4-b]pyridin-3-one | 4,6-dimethyl-2-[2-[3-methyl-4-(3-methylphenyl)piperazin-1-yl]-2-oxoethyl]-[1,2]thiazolo[5,4-b]pyridin-3-one | MLS000118900 | SMR000095840 | cid_5309798

Type

Small organic molecule

Emp. Form.

C22H26N4O2S

Mol. Mass.

410.532

SMILES

CC1CN(CCN1c1cccc(C)c1)C(=O)Cn1sc2nc(C)cc(C)c2c1=O

Structure