Ki Summary

Reaction Details

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Target

Regulator of G-protein signaling 16

Ligand

BDBM62219

Substrate/Competitor

n/a

Meas. Tech.

Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS16-Galphao for SAR Compounds

EC50

30000±0 nM

Citation

PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS16-Galphao for SAR Compounds PubChem Bioassay(2010)[AID]

More Info.:

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Regulator of G-protein signaling 16

Name:

Regulator of G-protein signaling 16

Synonyms:

RGS16 | RGS16_HUMAN | RGSR | Regulator of G-protein signaling 16 (RGS16) | regulator of G-protein signalling 16

Type:

Enzyme Catalytic Domain

Mol. Mass.:

22748.87

Organism:

Homo sapiens (Human)

Description:

gi_156416009

Residue:

202

Sequence:

MCRTLAAFPTTCLERAKEFKTRLGIFLHKSELGCDTGSTGKFEWGSKHSKENRNFSEDVL
GWRESFDLLLSSKNGVAAFHAFLKTEFSEENLEFWLACEEFKKIRSATKLASRAHQIFEE
FICSEAPKEVNIDHETHELTRMNLQTATATCFDAAQGKTRTLMEKDSYPRFLKSPAYRDL
AAQASAASATLSSCSLDEPSHT

BDBM62219

n/a

Name

BDBM62219

Synonyms:

2,4-dimethyl-6-[2-oxidanylidene-2-(4-phenylpiperazin-1-yl)ethyl]-7,8-dihydro-1,6-naphthyridin-5-one | 2,4-dimethyl-6-[2-oxo-2-(4-phenyl-1-piperazinyl)ethyl]-7,8-dihydro-1,6-naphthyridin-5-one | 2,4-dimethyl-6-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]-7,8-dihydro-1,6-naphthyridin-5-one | 6-[2-keto-2-(4-phenylpiperazino)ethyl]-2,4-dimethyl-7,8-dihydro-1,6-naphthyridin-5-one | KUC103674N | cid_44473130

Type

Small organic molecule

Emp. Form.

C22H26N4O2

Mol. Mass.

378.4674

SMILES

Cc1cc(C)c2C(=O)N(CC(=O)N3CCN(CC3)c3ccccc3)CCc2n1

Structure