Ki Summary

Reaction Details

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Target

Regulator of G-protein signaling 8

Ligand

BDBM43363

Substrate/Competitor

n/a

Meas. Tech.

Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao for SAR Compounds

EC50

78±n/a nM

Citation

PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao for SAR Compounds PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Regulator of G-protein signaling 8

Name:

Regulator of G-protein signaling 8

Synonyms:

RGS8 | RGS8_HUMAN | Regulator of G-protein signaling 8 (RGS8)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

20925.80

Organism:

Homo sapiens (Human)

Description:

gi_74355113

Residue:

180

Sequence:

MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVL
LSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPRE
VNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS

BDBM43363

n/a

Name

BDBM43363

Synonyms:

2,5-bis(chloranyl)-3-piperidin-1-yl-6-(2-piperidin-1-yl-1,3-thiazol-5-yl)cyclohexa-2,5-diene-1,4-dione | 2,5-dichloro-3-(1-piperidinyl)-6-[2-(1-piperidinyl)-1,3-thiazol-5-yl]benzo-1,4-quinone | 2,5-dichloro-3-(1-piperidinyl)-6-[2-(1-piperidinyl)-5-thiazolyl]cyclohexa-2,5-diene-1,4-dione | 2,5-dichloro-3-piperidin-1-yl-6-(2-piperidin-1-yl-1,3-thiazol-5-yl)cyclohexa-2,5-diene-1,4-dione | 2,5-dichloro-3-piperidino-6-(2-piperidinothiazol-5-yl)-p-benzoquinone | MLS000550549 | SMR000115104 | cid_406171

Type

Small organic molecule

Emp. Form.

C19H21Cl2N3O2S

Mol. Mass.

426.36

SMILES

ClC1=C(N2CCCCC2)C(=O)C(Cl)=C(c2cnc(s2)N2CCCCC2)C1=O |c:1,t:13|

Structure