Ki Summary

Reaction Details

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Target

Regulator of G-protein signaling 8

Ligand

BDBM34702

Substrate/Competitor

n/a

Meas. Tech.

Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao for SAR Compounds

EC50

318±n/a nM

Citation

PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao for SAR Compounds PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Regulator of G-protein signaling 8

Name:

Regulator of G-protein signaling 8

Synonyms:

RGS8 | RGS8_HUMAN | Regulator of G-protein signaling 8 (RGS8)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

20925.80

Organism:

Homo sapiens (Human)

Description:

gi_74355113

Residue:

180

Sequence:

MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVL
LSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPRE
VNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS

BDBM34702

n/a

Name

BDBM34702

Synonyms:

(4E)-2,3-dihydroxy-4-[[(4-methyl-2-methylimino-1,3-thiazol-3-yl)amino]methylidene]cyclohexa-2,5-dien-1-one | (4E)-2,3-dihydroxy-4-[[(4-methyl-2-methylimino-3-thiazolyl)amino]methylidene]-1-cyclohexa-2,5-dienone | (4E)-2,3-dihydroxy-4-[[(4-methyl-2-methylimino-4-thiazolin-3-yl)amino]methylene]cyclohexa-2,5-dien-1-one | (4E)-4-[[(4-methyl-2-methylimino-1,3-thiazol-3-yl)amino]methylidene]-2,3-bis(oxidanyl)cyclohexa-2,5-dien-1-one | (4Z)-2,3-dihydroxy-4-[[(4-methyl-2-methylimino-4-thiazolin-3-yl)amino]methylene]cyclohexa-2,5-dien-1-one | MLS000564160 | SMR000151701 | cid_5834362

Type

Small organic molecule

Emp. Form.

C12H13N3O3S

Mol. Mass.

279.315

SMILES

CN=c1scc(C)n1N=Cc1ccc(O)c(O)c1O |w:8.8,1.0|

Structure