| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 60S ribosomal protein L19-A |
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| Ligand | BDBM25116 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically RPL19A based on MLPCN hits |
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| EC50 | 825±n/a nM |
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| Citation |  PubChem, PC Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically RPL19A based on MLPCN hits PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| 60S ribosomal protein L19-A |
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| Name: | 60S ribosomal protein L19-A |
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| Synonyms: | RL19A_YEAST | RPL19A | RPL23A | YL14A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 21739.62 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | gi_536029 |
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| Residue: | 189 |
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| Sequence: | MANLRTQKRLAASVVGVGKRKVWLDPNETSEIAQANSRNAIRKLVKNGTIVKKAVTVHSK
SRTRAHAQSKREGRHSGYGKRKGTREARLPSQVVWIRRLRVLRRLLAKYRDAGKIDKHLY
HVLYKESKGNAFKHKRALVEHIIQAKADAQREKALNEEAEARRLKNRAARDRRAQRVAEK
RDALLKEDA
|
|
|
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| BDBM25116 |
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| n/a |
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| Name | BDBM25116 |
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| Synonyms: | 1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | CHEMBL306380 | PP1 | US10688093, Compound PP1 (Pfizer) | US10807986, Comparative compound 1 | US11046696, Compound 1 of Comparative Examples | US11701353, PP1 (Pfizer) | cid_1400 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H19N5 |
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| Mol. Mass. | 281.3556 |
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| SMILES | Cc1ccc(cc1)-c1nn(c2ncnc(N)c12)C(C)(C)C |
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| Structure | 
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|---|
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