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Reaction Details
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TargetApelin receptor
LigandBDBM21629
Substrate/Competitorn/a
Meas. Tech.Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay
IC50 1820±n/a nM
Citation PubChem, PC Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay(2010)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Apelin receptor
Name:Apelin receptor
Synonyms:AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:Enzyme Catalytic Domain
Mol. Mass.:42664.06
Organism:Homo sapiens (Human)
Description:P35414
Residue:380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD
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  Blast E-value cutoff:
BDBM21629
n/a
NameBDBM21629
Synonyms:3-(4-methylphenyl)-5H-indeno[1,2-c]pyridazin-5-one | Indeno[1,2-c]pyridazin-5-one | cid_2767330
TypeSmall organic molecule
Emp. Form.C18H12N2O
Mol. Mass.272.3007
SMILESCc1ccc(cc1)-c1cc2C(=O)c3ccccc3-c2nn1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: