Ki Summary

Reaction Details

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Target

DNA damage-inducible transcript 3 protein

Ligand

BDBM68139

Substrate/Competitor

n/a

Meas. Tech.

Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress

IC50

260±n/a nM

Citation

PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay(2010)[AID]

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Get all data from this article, Solution Info, Assay Method

DNA damage-inducible transcript 3 protein

Name:

DNA damage-inducible transcript 3 protein

Synonyms:

Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153

Type:

Enzyme Catalytic Domain

Mol. Mass.:

19175.17

Organism:

Mus musculus

Description:

gi_160707929

Residue:

168

Sequence:

MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASL
AWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMK
EKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA

BDBM68139

n/a

Name

BDBM68139

Synonyms:

MLS000621996 | N-[3-[4-(2-fluorophenyl)-1-piperazinyl]propyl]-2-[2-[(2-sulfanylidene-1H-quinazolin-4-yl)amino]-4-thiazolyl]acetamide | N-[3-[4-(2-fluorophenyl)piperazin-1-yl]propyl]-2-[2-[(2-sulfanylidene-1H-quinazolin-4-yl)amino]-1,3-thiazol-4-yl]acetamide | N-[3-[4-(2-fluorophenyl)piperazin-1-yl]propyl]-2-[2-[(2-sulfanylidene-1H-quinazolin-4-yl)amino]-1,3-thiazol-4-yl]ethanamide | N-[3-[4-(2-fluorophenyl)piperazino]propyl]-2-[2-[(2-thioxo-1H-quinazolin-4-yl)amino]thiazol-4-yl]acetamide | N-{3-[4-(2-fluorophenyl)piperazin-1-yl]propyl}-2-{2-[(2-thioxo-1,2-dihydroquinazolin-4-yl)amino]-1,3-thiazol-4-yl}acetamide | SMR000310923 | cid_16195306

Type

Small organic molecule

Emp. Form.

C26H28FN7OS2

Mol. Mass.

537.675

SMILES

Fc1ccccc1N1CCN(CCCNC(=O)Cc2csc(Nc3[nH]c(=S)nc4ccccc34)n2)CC1

Structure