Reaction Details |
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Target | ATP-dependent molecular chaperone HSP82 |
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Ligand | BDBM68251 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FP Assay |
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IC50 | 2.5e+2±n/a nM |
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Citation | Proisy, N; Sharp, SY; Boxall, K; Connelly, S; Roe, SM; Prodromou, C; Slawin, AM; Pearl, LH; Workman, P; Moody, CJ Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. Chem Biol13:1203-15 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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ATP-dependent molecular chaperone HSP82 |
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Name: | ATP-dependent molecular chaperone HSP82 |
Synonyms: | 82 kDa heat shock protein | ATP-dependent molecular chaperone HSP82 | HSP82 | HSP82_YEAST | HSP90 | Heat Shock Protein 90 (Hsp90) | Heat shock protein Hsp90 heat-inducible isoform |
Type: | Molecular Chaperone |
Mol. Mass.: | 81369.08 |
Organism: | Saccharomyces cerevisiae |
Description: | Histidine-tagged yeast HSP90 was transformed into E. coli and purified (>90%) by metal affinity, gel filtration, and ion-exchange chromatography. |
Residue: | 709 |
Sequence: | MASETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYKSLSDPKQLETEP
DLFIRITPKPEQKVLEIRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQF
GVGFYSLFLVADRVQVISKSNDDEQYIWESNAGGSFTVTLDEVNERIGRGTILRLFLKDD
QLEYLEEKRIKEVIKRHSEFVAYPIQLVVTKEVEKEVPIPEEEKKDEEKKDEEKKDEDDK
KPKLEEVDEEEEKKPKTKKVKEEVQEIEELNKTKPLWTRNPSDITQEEYNAFYKSISNDW
EDPLYVKHFSVEGQLEFRAILFIPKRAPFDLFESKKKKNNIKLYVRRVFITDEAEDLIPE
WLSFVKGVVDSEDLPLNLSREMLQQNKIMKVIRKNIVKKLIEAFNEIAEDSEQFEKFYSA
FSKNIKLGVHEDTQNRAALAKLLRYNSTKSVDELTSLTDYVTRMPEHQKNIYYITGESLK
AVEKSPFLDALKAKNFEVLFLTDPIDEYAFTQLKEFEGKTLVDITKDFELEETDEEKAER
EKEIKEYEPLTKALKEILGDQVEKVVVSYKLLDAPAAIRTGQFGWSANMERIMKAQALRD
SSMSSYMSSKKTFEISPKSPIIKELKKRVDEGGAQDKTVKDLTKLLYETALLTSGFSLDE
PTSFASRINRLISLGLNIDEDEETETAPEASTAAPVEEVPADTEMEEVD
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BDBM68251 |
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n/a |
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Name | BDBM68251 |
Synonyms: | Microlactone, 16b |
Type | Small organic molecule |
Emp. Form. | C18H21ClO6 |
Mol. Mass. | 368.809 |
SMILES | CC1C[C@H]2O[C@@H]2CCCCC(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1 |r,w:1.0| |
Structure |
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