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TargetATP-dependent molecular chaperone HSP82
LigandBDBM68265
Substrate/Competitorn/a
Meas. Tech.FP Assay
IC50 2.63e+3±n/a nM
Citation Proisy, NSharp, SYBoxall, KConnelly, SRoe, SMProdromou, CSlawin, AMPearl, LHWorkman, PMoody, CJ Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. Chem Biol13:1203-15 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
ATP-dependent molecular chaperone HSP82
Name:ATP-dependent molecular chaperone HSP82
Synonyms:82 kDa heat shock protein | ATP-dependent molecular chaperone HSP82 | HSP82 | HSP82_YEAST | HSP90 | Heat Shock Protein 90 (Hsp90) | Heat shock protein Hsp90 heat-inducible isoform
Type:Molecular Chaperone
Mol. Mass.:81369.08
Organism:Saccharomyces cerevisiae
Description:Histidine-tagged yeast HSP90 was transformed into E. coli and purified (>90%) by metal affinity, gel filtration, and ion-exchange chromatography.
Residue:709
Sequence:
MASETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYKSLSDPKQLETEP
DLFIRITPKPEQKVLEIRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQF
GVGFYSLFLVADRVQVISKSNDDEQYIWESNAGGSFTVTLDEVNERIGRGTILRLFLKDD
QLEYLEEKRIKEVIKRHSEFVAYPIQLVVTKEVEKEVPIPEEEKKDEEKKDEEKKDEDDK
KPKLEEVDEEEEKKPKTKKVKEEVQEIEELNKTKPLWTRNPSDITQEEYNAFYKSISNDW
EDPLYVKHFSVEGQLEFRAILFIPKRAPFDLFESKKKKNNIKLYVRRVFITDEAEDLIPE
WLSFVKGVVDSEDLPLNLSREMLQQNKIMKVIRKNIVKKLIEAFNEIAEDSEQFEKFYSA
FSKNIKLGVHEDTQNRAALAKLLRYNSTKSVDELTSLTDYVTRMPEHQKNIYYITGESLK
AVEKSPFLDALKAKNFEVLFLTDPIDEYAFTQLKEFEGKTLVDITKDFELEETDEEKAER
EKEIKEYEPLTKALKEILGDQVEKVVVSYKLLDAPAAIRTGQFGWSANMERIMKAQALRD
SSMSSYMSSKKTFEISPKSPIIKELKKRVDEGGAQDKTVKDLTKLLYETALLTSGFSLDE
PTSFASRINRLISLGLNIDEDEETETAPEASTAAPVEEVPADTEMEEVD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM68265
n/a
NameBDBM68265
Synonyms:Microlactone, 18
TypeSmall organic molecule
Emp. Form.C18H20Br2O5
Mol. Mass.476.156
SMILESOc1c(Br)c(O)c2c(CC(=O)CCCCCC=CCCOC2=O)c1Br |w:18.17,16.15|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: