Reaction Details |
| Report a problem with these data |
Target | ATP-dependent molecular chaperone HSP82 |
---|
Ligand | BDBM68265 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | FP Assay |
---|
IC50 | 2.63e+3±n/a nM |
---|
Citation | Proisy, N; Sharp, SY; Boxall, K; Connelly, S; Roe, SM; Prodromou, C; Slawin, AM; Pearl, LH; Workman, P; Moody, CJ Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. Chem Biol13:1203-15 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
ATP-dependent molecular chaperone HSP82 |
---|
Name: | ATP-dependent molecular chaperone HSP82 |
Synonyms: | 82 kDa heat shock protein | ATP-dependent molecular chaperone HSP82 | HSP82 | HSP82_YEAST | HSP90 | Heat Shock Protein 90 (Hsp90) | Heat shock protein Hsp90 heat-inducible isoform |
Type: | Molecular Chaperone |
Mol. Mass.: | 81369.08 |
Organism: | Saccharomyces cerevisiae |
Description: | Histidine-tagged yeast HSP90 was transformed into E. coli and purified (>90%) by metal affinity, gel filtration, and ion-exchange chromatography. |
Residue: | 709 |
Sequence: | MASETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYKSLSDPKQLETEP
DLFIRITPKPEQKVLEIRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQF
GVGFYSLFLVADRVQVISKSNDDEQYIWESNAGGSFTVTLDEVNERIGRGTILRLFLKDD
QLEYLEEKRIKEVIKRHSEFVAYPIQLVVTKEVEKEVPIPEEEKKDEEKKDEEKKDEDDK
KPKLEEVDEEEEKKPKTKKVKEEVQEIEELNKTKPLWTRNPSDITQEEYNAFYKSISNDW
EDPLYVKHFSVEGQLEFRAILFIPKRAPFDLFESKKKKNNIKLYVRRVFITDEAEDLIPE
WLSFVKGVVDSEDLPLNLSREMLQQNKIMKVIRKNIVKKLIEAFNEIAEDSEQFEKFYSA
FSKNIKLGVHEDTQNRAALAKLLRYNSTKSVDELTSLTDYVTRMPEHQKNIYYITGESLK
AVEKSPFLDALKAKNFEVLFLTDPIDEYAFTQLKEFEGKTLVDITKDFELEETDEEKAER
EKEIKEYEPLTKALKEILGDQVEKVVVSYKLLDAPAAIRTGQFGWSANMERIMKAQALRD
SSMSSYMSSKKTFEISPKSPIIKELKKRVDEGGAQDKTVKDLTKLLYETALLTSGFSLDE
PTSFASRINRLISLGLNIDEDEETETAPEASTAAPVEEVPADTEMEEVD
|
|
|
BDBM68265 |
---|
n/a |
---|
Name | BDBM68265 |
Synonyms: | Microlactone, 18 |
Type | Small organic molecule |
Emp. Form. | C18H20Br2O5 |
Mol. Mass. | 476.156 |
SMILES | Oc1c(Br)c(O)c2c(CC(=O)CCCCCC=CCCOC2=O)c1Br |w:18.17,16.15| |
Structure |
|