Reaction Details |
| Report a problem with these data |
Target | Beta-hexosaminidase subunit alpha |
---|
Ligand | BDBM50106194 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Enzyme Inhibition Assay |
---|
Temperature | 298.15±0 K |
---|
IC50 | 1.8e+4± 1.5e+3 nM |
---|
Citation | Tropak, MB; Blanchard, JE; Withers, SG; Brown, ED; Mahuran, D High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones. Chem Biol14:153-64 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Beta-hexosaminidase subunit alpha |
---|
Name: | Beta-hexosaminidase subunit alpha |
Synonyms: | Beta-N-acetylhexosaminidase subunit alpha | Beta-hexosaminidase subunit alpha (HexA) | HEXA | HEXA_HUMAN |
Type: | Protein |
Mol. Mass.: | 60688.46 |
Organism: | Homo sapiens (Human) |
Description: | P06865 |
Residue: | 529 |
Sequence: | MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSV
LDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTI
NDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHY
LPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVK
EVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEF
MSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLL
DIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPW
YLNRISYGPDWKDFYIVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAV
AERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT
|
|
|
BDBM50106194 |
---|
n/a |
---|
Name | BDBM50106194 |
Synonyms: | 1,3-dioxo-1H-benz[de]isoquinoline | 1,8-Naphthalimide | 1H-benzo[de]isoquinoline-1,3(2H)-dione | BTB12933 | Benzo[de]isoquinoline-1,3-dione | CHEMBL339586 |
Type | Small organic molecule |
Emp. Form. | C12H7NO2 |
Mol. Mass. | 197.1895 |
SMILES | O=C1NC(=O)c2cccc3cccc1c23 |
Structure |
|