| Reaction Details |
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 | Report a problem with these data |
| Target | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Ligand | BDBM68278 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FabH Enzyme Assay |
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| pH | 7±0 |
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| Temperature | 310.15±0 K |
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| IC50 | 1.2e+3± 7e+2 nM |
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| Citation |  Alhamadsheh, MM; Musayev, F; Komissarov, AA; Sachdeva, S; Wright, HT; Scarsdale, N; Florova, G; Reynolds, KA Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes. Chem Biol14:513-24 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Name: | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Synonyms: | 3-oxoacyl-[acyl-carrier-protein] synthase | 3-oxoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-ACP synthase III (FabH) | FABH_MYCTO | fabH |
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| Type: | Enzyme |
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| Mol. Mass.: | 34865.07 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | P9WNG2 |
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| Residue: | 335 |
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| Sequence: | MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDES
AASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSA
GCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETP
FQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRR
AMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMA
ELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG
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| BDBM68278 |
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| n/a |
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| Name | BDBM68278 |
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| Synonyms: | Decyl-CoA disulfide 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H54N7O16P3S2 |
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| Mol. Mass. | 925.838 |
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| SMILES | CCCCCCCCCCSSCCNC(=O)CCNC(=O)C(O)C(C)(C)OP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n1cnc2c(N)ncnc12 |
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| Structure | 
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