Ki Summary

Reaction Details

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Target

Importin subunit alpha-1

Ligand

BDBM75003

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.

EC50

7289±n/a nM

Citation

PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Importin subunit alpha-1

Name:

Importin subunit alpha-1

Synonyms:

IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57852.15

Organism:

Homo sapiens (Human)

Description:

gi_119609447

Residue:

529

Sequence:

MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF

BDBM75003

n/a

Name

BDBM75003

Synonyms:

9-methyl-N-(6-methyl-2-pyridinyl)-4H-thieno[3,2-c][1]benzopyran-2-carboxamide | 9-methyl-N-(6-methyl-2-pyridyl)-4H-thieno[3,2-c]chromene-2-carboxamide | 9-methyl-N-(6-methylpyridin-2-yl)-4H-thieno[3,2-c]chromene-2-carboxamide | MLS000731527 | SMR000309802 | cid_16194088

Type

Small organic molecule

Emp. Form.

C19H16N2O2S

Mol. Mass.

336.408

SMILES

Cc1cccc(NC(=O)c2cc3COc4cccc(C)c4-c3s2)n1

Structure