Ki Summary

Reaction Details

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Target

Importin subunit alpha-1

Ligand

BDBM75018

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.

EC50

9013±n/a nM

Citation

PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Importin subunit alpha-1

Name:

Importin subunit alpha-1

Synonyms:

IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57852.15

Organism:

Homo sapiens (Human)

Description:

gi_119609447

Residue:

529

Sequence:

MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF

BDBM75018

n/a

Name

BDBM75018

Synonyms:

3-(2-hydroxyethyl)-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]-4-quinazolinone | 3-(2-hydroxyethyl)-2-[(E)-2-(2-methyl-1H-indol-3-yl)ethenyl]quinazolin-4-one | 3-(2-hydroxyethyl)-2-[(E)-2-(2-methyl-1H-indol-3-yl)vinyl]quinazolin-4-one | MLS000764715 | SMR000290320 | cid_5732079

Type

Small organic molecule

Emp. Form.

C21H19N3O2

Mol. Mass.

345.3945

SMILES

Cc1[nH]c2ccccc2c1\C=C\c1nc2ccccc2c(=O)n1CCO

Structure