| Reaction Details |
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 | Report a problem with these data |
| Target | Importin subunit alpha-1 |
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| Ligand | BDBM75030 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. |
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| EC50 | >500000±n/a nM |
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| Citation |  PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Importin subunit alpha-1 |
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| Name: | Importin subunit alpha-1 |
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| Synonyms: | IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57852.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_119609447 |
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| Residue: | 529 |
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| Sequence: | MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
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| BDBM75030 |
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| n/a |
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| Name | BDBM75030 |
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| Synonyms: | 2-(2,6-dimethylmorpholin-4-yl)-5-ethanoyl-6-methyl-pyridine-3-carbonitrile | 5-acetyl-2-(2,6-dimethyl-4-morpholinyl)-6-methyl-3-pyridinecarbonitrile | 5-acetyl-2-(2,6-dimethylmorpholin-4-yl)-6-methylpyridine-3-carbonitrile | 5-acetyl-2-(2,6-dimethylmorpholino)-6-methyl-nicotinonitrile | 5-acetyl-2-(2,6-dimethylmorpholino)-6-methylnicotinonitrile | MLS000707002 | SMR000334399 | cid_2769098 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H19N3O2 |
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| Mol. Mass. | 273.3303 |
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| SMILES | CC1CN(CC(C)O1)c1nc(C)c(cc1C#N)C(C)=O |
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| Structure | 
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