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TargetImportin subunit alpha-1
LigandBDBM53108
Substrate/Competitorn/a
Meas. Tech.Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50 4529±n/a nM
Citation PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Importin subunit alpha-1
Name:Importin subunit alpha-1
Synonyms:IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:Enzyme Catalytic Domain
Mol. Mass.:57852.15
Organism:Homo sapiens (Human)
Description:gi_119609447
Residue:529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
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  Blast E-value cutoff:
BDBM53108
n/a
NameBDBM53108
Synonyms:2-[(6,7-dihydroxy-2-keto-chromen-4-yl)methylamino]benzoic acid methyl ester | 2-[(6,7-dihydroxy-2-oxo-1-benzopyran-4-yl)methylamino]benzoic acid methyl ester | MLS001214762 | SMR000543544 | cid_5574594 | methyl 2-[(6,7-dihydroxy-2-oxochromen-4-yl)methylamino]benzoate | methyl 2-[[6,7-bis(oxidanyl)-2-oxidanylidene-chromen-4-yl]methylamino]benzoate
TypeSmall organic molecule
Emp. Form.C18H15NO6
Mol. Mass.341.3148
SMILESCOC(=O)c1ccccc1NCc1cc(=O)oc2cc(O)c(O)cc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: