| Reaction Details |
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 | Report a problem with these data |
| Target | Integrin alpha-4 |
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| Ligand | BDBM39009 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose Response of primary screening hit compounds for Identification of VLA-4 Allosteric Modulators |
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| EC50 | 2670±n/a nM |
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| Citation |  PubChem, PC Dose Response of primary screening hit compounds for Identification of VLA-4 Allosteric Modulators PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Integrin alpha-4 |
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| Name: | Integrin alpha-4 |
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| Synonyms: | CD49 antigen-like family member D | CD49D | CD49d antigen | CD_antigen=CD49d | ITA4_HUMAN | ITGA4 | Integrin alpha-4 | Integrin alpha-4/beta-7 | Integrin alpha-IV | Integrin alpha4 | VLA-4 | VLA-4 subunit alpha | integrin alpha 4 precursor | integrin alpha-4 precursor |
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| Type: | Membrane Protein |
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| Mol. Mass.: | 114897.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P13612 |
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| Residue: | 1032 |
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| Sequence: | MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHS
HGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLE
ERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRI
APCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLD
KQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGK
KLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVG
SDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEG
LQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVN
RTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGT
SDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQ
PILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLN
VSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDH
LSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHG
FVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLF
NILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNF
LCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVA
HVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRD
SWSYINSKSNDD
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| BDBM39009 |
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| n/a |
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| Name | BDBM39009 |
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| Synonyms: | 6-(4-bromophenyl)-2-(methylsulfinyl)-4-phenylnicotinonitrile | 6-(4-bromophenyl)-2-methylsulfinyl-4-phenyl-3-pyridinecarbonitrile | 6-(4-bromophenyl)-2-methylsulfinyl-4-phenyl-nicotinonitrile | 6-(4-bromophenyl)-2-methylsulfinyl-4-phenyl-pyridine-3-carbonitrile | 6-(4-bromophenyl)-2-methylsulfinyl-4-phenylpyridine-3-carbonitrile | MLS000048185 | SMR000073426 | cid_1316704 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H13BrN2OS |
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| Mol. Mass. | 397.288 |
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| SMILES | CS(=O)c1nc(cc(-c2ccccc2)c1C#N)-c1ccc(Br)cc1 |
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| Structure | 
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