Ki Summary

Reaction Details

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Target

Intestinal-type alkaline phosphatase

Ligand

BDBM39617

Substrate/Competitor

n/a

Meas. Tech.

Dose Response confirmation of uHTS hits from a small molecule inhibitors of human intestinal alkaline phosphatase via a luminescent assay

IC50

1760±n/a nM

Citation

PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of human intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Intestinal-type alkaline phosphatase

Name:

Intestinal-type alkaline phosphatase

Synonyms:

ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN

Type:

PROTEIN

Mol. Mass.:

56804.94

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1278525

Residue:

528

Sequence:

MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLG
DGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLC
GVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYA
HTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADA
SQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRD
PTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERA
GQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVF
NSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHV
MAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP

BDBM39617

n/a

Name

BDBM39617

Synonyms:

3-[5-(methylamino)-1,3,4-thiadiazol-2-yl]-1-benzopyran-2-one | 3-[5-(methylamino)-1,3,4-thiadiazol-2-yl]-2H-chromen-2-one | 3-[5-(methylamino)-1,3,4-thiadiazol-2-yl]chromen-2-one | 3-[5-(methylamino)-1,3,4-thiadiazol-2-yl]coumarin | MLS000094728 | SMR000030281 | cid_3244772

Type

Small organic molecule

Emp. Form.

C12H9N3O2S

Mol. Mass.

259.284

SMILES

CNc1nnc(s1)-c1cc2ccccc2oc1=O

Structure