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TargetcAMP-dependent protein kinase catalytic subunit alpha
LigandBDBM2694
Substrate/Competitorhistone (type H IIas)
Meas. Tech.PKA assay
IC50 2000±n/a nM
Citation Toullec, DPianetti, PCoste, HBellevergue, PGrand-Perret, TAjakane, MBaudet, VBoissin, PBoursier, ELoriolle, F The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem266:15771-81 (1991) [PubMed]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
cAMP-dependent protein kinase catalytic subunit alpha
Name:cAMP-dependent protein kinase catalytic subunit alpha
Synonyms:KAPCA_RAT | PKA, catalytic subunit | Prkaca | cAMP-Dependent Protein Kinase (PKA) | cAMP-dependent protein kinase alpha-catalytic subunit
Type:Enzyme catalytic subunit
Mol. Mass.:40627.70
Organism:Rattus norvegicus (rat)
Description:The catalytic subunit of cAMP-dependent protein kinase (PKA) was used in the assay. It did not require cAMP for activity.
Residue:351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWEDPSQNTAQLDHFDRIKTLGTGSFGRVML
VKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM2694
histone (type H IIas)
Name:histone (type H IIas)
Synonyms:n/a
Type:Peptide
Mol. Mass.:13378.65
Organism:n/a
Description:20 uM [gamma-32P]ATP as co-substrate.
Residue:124
Sequence:
MSGRGKGGKVKGKAKSRSNRAGLQFPVGRIHRLLRKGNYAERVGAGAPVYLAAVMEYLAA
EVLELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIQAVLLPKKT
EKKA