| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA (cytosine-5)-methyltransferase 3A |
|---|
| Ligand | BDBM46243 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | SAR Selectivity Analysis of small molecule inhibitors of PEST using pCAP in a fluorescence assay |
|---|
| IC50 | 5080±n/a nM |
|---|
| Citation |  PubChem, PC SAR Selectivity Analysis of small molecule inhibitors of PEST using pCAP in a fluorescence assay PubChem Bioassay(2010)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| DNA (cytosine-5)-methyltransferase 3A |
|---|
| Name: | DNA (cytosine-5)-methyltransferase 3A |
|---|
| Synonyms: | DNA (cytosine-5)-methyltransferase 3A | DNA MTase HsaIIIA | DNA methyltransferase HsaIIIA | DNM3A_HUMAN | DNMT3A | DNMT3A2/3L complex | M.HsaIIIA | tyrosine-protein phosphatase non-receptor type 12 isoform 2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 101857.24 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1510405 |
|---|
| Residue: | 912 |
|---|
| Sequence: | MPAMPSSGPGDTSSSAAEREEDRKDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPV
ESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGEG
AAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSL
RQRPMPRLTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVE
EASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGKL
RGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYN
KQPMYRKAIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPK
GLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERLV
YEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTIC
CGGREVLMCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRRED
WPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRY
IASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPAR
KGLYEGTGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMI
DAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNSI
KQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRH
LFAPLKEYFACV
|
|
|
|---|
| BDBM46243 |
|---|
| n/a |
|---|
| Name | BDBM46243 |
|---|
| Synonyms: | 4-[[2-chloranyl-4-[(E)-2-cyano-2-(3-fluorophenyl)ethenyl]-6-ethoxy-phenoxy]methyl]benzoic acid | 4-[[2-chloro-4-[(E)-2-cyano-2-(3-fluorophenyl)ethenyl]-6-ethoxyphenoxy]methyl]benzoic acid | 4-[[2-chloro-4-[(E)-2-cyano-2-(3-fluorophenyl)vinyl]-6-ethoxy-phenoxy]methyl]benzoic acid | MLS-0412112.0001 | cid_2230267 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H19ClFNO4 |
|---|
| Mol. Mass. | 451.874 |
|---|
| SMILES | CCOc1cc(\C=C(\C#N)c2cccc(F)c2)cc(Cl)c1OCc1ccc(cc1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
