| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N] |
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| Ligand | BDBM2721 |
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| Substrate/Competitor | (rC)n.(dG)12-18 |
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| Meas. Tech. | HIV-1 RT Assay |
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| pH | 7.8±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 473±n/a nM |
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| Citation |  Hogberg, M; Sahlberg, C; Engelhardt, P; Noreen, R; Kangasmetsa, J; Johansson, NG; Oberg, B; Vrang, L; Zhang, H; Sahlberg, BL; Unge, T; Lovgren, S; Fridborg, K; Backbro, K Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues. J Med Chem42:4150-60 (1999) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Gag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N] |
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| Name: | Gag-Pol polyprotein [588-1027,K690N]/[588-1147,K690N] |
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| Synonyms: | EC: 2.7.7.49 | HIV-1 Reverse Transcriptase Mutant (K103N) |
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| Type: | Protein Complex |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Gag-Pol polyprotein [588-1147,K690N] |
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| Synonyms: | HIV-1 Reverse Transcriptase Mutant (K103N) Chain A | POL_HV1H2 | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 64471.33 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[588-1147,K690N] |
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| Residue: | 560 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL
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| Component 2 |
| Name: | Gag-Pol polyprotein [588-1027,K690N] |
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| Synonyms: | HIV-1 Reverse Transcriptase Mutant (K103N) Chain B | POL_HV1H2 | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 51280.01 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[588-1027,K690N] |
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| Residue: | 440 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYNLEKEPIVGAETF
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| BDBM2721 |
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| (rC)n.(dG)12-18 |
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| Name: | (rC)n.(dG)12-18 |
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| Synonyms: | n/a |
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| Type: | RNA-DNA duplex |
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| Mol. Mass.: | 358.43 |
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| Organism: | n/a |
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| Description: | The incorporation of Tritium-labeled dGTP onto a poly(rC):oligo(dG)template:primer.
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| Residue: | 3 |
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| Sequence: | |
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