| Reaction Details |
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 | Report a problem with these data |
| Target | Protein Mdm4 |
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| Ligand | BDBM79632 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction in luminescent format |
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| IC50 | 3580±n/a nM |
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| Citation |  PubChem, PC Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction in luminescent format PubChem Bioassay(2011)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Protein Mdm4 |
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| Name: | Protein Mdm4 |
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| Synonyms: | Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4 |
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| Type: | Oncoprotein |
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| Mol. Mass.: | 54842.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose. |
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| Residue: | 490 |
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| Sequence: | MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF
LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS
EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
IQLVIKVFIA
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| BDBM79632 |
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| n/a |
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| Name | BDBM79632 |
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| Synonyms: | 2-hydroxy-6-isopropyl-cyclohepta-2,4,6-trien-1-one | 2-hydroxy-6-propan-2-yl-1-cyclohepta-2,4,6-trienone | 2-hydroxy-6-propan-2-ylcyclohepta-2,4,6-trien-1-one | 2-oxidanyl-6-propan-2-yl-cyclohepta-2,4,6-trien-1-one | MLS001048906 | SMR000387099 | US9790158, 9 | cid_3611 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H12O2 |
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| Mol. Mass. | 164.2011 |
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| SMILES | CC(C)c1cccc(O)c(=O)c1 |
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| Structure | 
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