Ki Summary

Reaction Details

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Target

DNA dC->dU-editing enzyme APOBEC-3G

Ligand

BDBM80458

Substrate/Competitor

n/a

Meas. Tech.

Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen

Temperature

298.15±n/a K

IC50

814±79 nM

Comments

extracted

Citation

PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

DNA dC->dU-editing enzyme APOBEC-3G

Name:

DNA dC->dU-editing enzyme APOBEC-3G

Synonyms:

ABC3G_HUMAN | APOBEC3G

Type:

Enzyme Catalytic Domain

Mol. Mass.:

46419.54

Organism:

Homo sapiens (Human)

Description:

gi_13399304

Residue:

384

Sequence:

MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYS
ELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFV
ARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPK
YYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRG
FLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFIS
KNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQP
WDGLDEHSQDLSGRLRAILQNQEN

BDBM80458

n/a

Name

BDBM80458

Synonyms:

(1E,2E)-3-(2-nitrophenyl)acrylaldehyde (4,6-dipiperidin-1-yl-1,3,5-triazin-2-yl)hydrazone | (4,6-dipiperidino-s-triazin-2-yl)-[[(E)-3-(2-nitrophenyl)prop-2-enylidene]amino]amine | MLS000723636 | N-[[(E)-3-(2-nitrophenyl)prop-2-enylidene]amino]-4,6-bis(1-piperidinyl)-1,3,5-triazin-2-amine | N-[[(E)-3-(2-nitrophenyl)prop-2-enylidene]amino]-4,6-di(piperidin-1-yl)-1,3,5-triazin-2-amine | SMR000305231 | cid_16189284

Type

Small organic molecule

Emp. Form.

C22H28N8O2

Mol. Mass.

436.5101

SMILES

[O-][N+](=O)c1ccccc1CC=CN=Nc1nc(nc(n1)N1CCCCC1)N1CCCCC1 |w:13.14,11.12|

Structure