Ki Summary

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Target

DNA dC->dU-editing enzyme APOBEC-3A

Ligand

BDBM80526

Substrate/Competitor

n/a

Meas. Tech.

Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay

Temperature

298.15±n/a K

IC50

1910±n/a nM

Comments

extracted

Citation

PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

DNA dC->dU-editing enzyme APOBEC-3A

Name:

DNA dC->dU-editing enzyme APOBEC-3A

Synonyms:

ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A

Type:

Enzyme Catalytic Domain

Mol. Mass.:

23013.77

Organism:

Homo sapiens (Human)

Description:

gi_21955158

Residue:

199

Sequence:

MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAK
NLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHV
RLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLD
EHSQALSGRLRAILQNQGN

BDBM80526

n/a

Name

BDBM80526

Synonyms:

1-[2-Acetoxy-3-(1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yloxy)-propyl]-1-methyl-piperidinium | MLS000333810 | SMR000440175 | [1-(1-methylpiperidin-1-ium-1-yl)-3-[[(1S,4S)-4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl]oxy]propan-2-yl] acetate;iodide | [1-(1-methylpiperidin-1-ium-1-yl)-3-[[(1S,4S)-4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl]oxy]propan-2-yl] ethanoate;iodide | acetic acid [1-(1-methyl-1-piperidin-1-iumyl)-3-[[(1S,4S)-4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl]oxy]propan-2-yl] ester;iodide | acetic acid [1-[(1-methylpiperidin-1-ium-1-yl)methyl]-2-[(1S,4S)-1,7,7-trimethylnorbornan-2-yl]oxy-ethyl] ester;iodide | cid_16682563

Type

Small organic molecule

Emp. Form.

C21H38NO3

Mol. Mass.

352.5308

SMILES

CC(=O)OC(COC1C[C@@H]2CC[C@@]1(C)C2(C)C)C[N+]1(C)CCCCC1 |TLB:6:7:14:11.10|

Structure