Ki Summary

Reaction Details

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Target

Tropomyosin alpha-1 chain

Ligand

BDBM54999

Substrate/Competitor

n/a

Meas. Tech.

Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)

IC50

19681±n/a nM

Citation

PubChem, PC Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Tropomyosin alpha-1 chain

Name:

Tropomyosin alpha-1 chain

Synonyms:

TPM1 | TPM1_PIG | cardiac alpha tropomyosin

Type:

Enzyme Catalytic Domain

Mol. Mass.:

32681.01

Organism:

Sus scrofa

Description:

P42639

Residue:

284

Sequence:

MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKY
SEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA
DESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAE
ERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAE
FAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI

BDBM54999

n/a

Name

BDBM54999

Synonyms:

5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxylic acid [2-[(6-amino-1-benzyl-2,4-diketo-pyrimidin-5-yl)-(2-methoxyethyl)amino]-2-keto-ethyl] ester | 5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxylic acid [2-[[6-amino-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-(2-methoxyethyl)amino]-2-oxoethyl] ester | MLS001080179 | SMR000711361 | [2-[(6-amino-1-benzyl-2,4-dioxopyrimidin-5-yl)-(2-methoxyethyl)amino]-2-oxoethyl] 5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxylate | [2-[[6-azanyl-2,4-bis(oxidanylidene)-1-(phenylmethyl)pyrimidin-5-yl]-(2-methoxyethyl)amino]-2-oxidanylidene-ethyl] 5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxylate | cid_24979394

Type

Small organic molecule

Emp. Form.

C24H26N4O6S

Mol. Mass.

498.551

SMILES

COCCN(C(=O)COC(=O)c1cc2CCCc2s1)c1c(N)n(Cc2ccccc2)c(=O)[nH]c1=O

Structure