Ki Summary

Reaction Details

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Target

Cysteine protease ATG4B

Ligand

BDBM80901

Substrate/Competitor

n/a

Meas. Tech.

Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B.

IC50

1620±n/a nM

Citation

PubChem, PC Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. PubChem Bioassay(2011)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Cysteine protease ATG4B

Name:

Cysteine protease ATG4B

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

44279.79

Organism:

Homo sapiens (Human)

Description:

gi_47132611

Residue:

393

Sequence:

MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPA
IGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKD
SYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIR
RLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYV
ETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFH
CQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLA
CPDVLNLSLDSSDVERLERFFDSEDEDFEILSL

BDBM80901

n/a

Name

BDBM80901

Synonyms:

2-[(1-ketoisochroman-3-carbonyl)amino]-4,5,6,7-tetrahydrobenzothiophene-3-carboxylic acid methyl ester | 2-[[oxo-(1-oxo-3,4-dihydro-1H-2-benzopyran-3-yl)methyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid methyl ester | MLS000724771 | SMR000236924 | cid_4906535 | methyl 2-[(1-oxidanylidene-3,4-dihydroisochromen-3-yl)carbonylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate | methyl 2-[(1-oxo-3,4-dihydroisochromene-3-carbonyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

Type

Small organic molecule

Emp. Form.

C20H19NO5S

Mol. Mass.

385.434

SMILES

COC(=O)c1c(NC(=O)C2Cc3ccccc3C(=O)O2)sc2CCCCc12

Structure