BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCysteine protease ATG4B
LigandBDBM34905
Substrate/Competitorn/a
Meas. Tech.Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B.
IC50 2840±n/a nM
Citation PubChem, PC Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. PubChem Bioassay(2011)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cysteine protease ATG4B
Name:Cysteine protease ATG4B
Synonyms:APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:Enzyme Catalytic Domain
Mol. Mass.:44279.79
Organism:Homo sapiens (Human)
Description:gi_47132611
Residue:393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPA
IGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKD
SYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIR
RLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYV
ETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFH
CQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLA
CPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM34905
n/a
NameBDBM34905
Synonyms:1,6-dimethyl-3-propyl-pyrimido[5,4-e][1,2,4]triazine-5,7-dione | 1,6-dimethyl-3-propyl-pyrimido[5,4-e][1,2,4]triazine-5,7-quinone | 1,6-dimethyl-3-propylpyrimido[5,4-e][1,2,4]triazine-5,7-dione | MLS000718932 | SMR000291200 | US9073941, 617 | cid_3164059
TypeSmall organic molecule
Emp. Form.C10H13N5O2
Mol. Mass.235.2425
SMILESCCCc1nn(C)c2nc(=O)n(C)c(=O)c2n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: