| Reaction Details |
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 | Report a problem with these data |
| Target | Lanosterol 14-alpha-demethylase |
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| Ligand | BDBM81310 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 6±0 |
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| Kd | 1.4e+2±n/a nM |
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| Citation |  Lepesheva, GI; Ott, RD; Hargrove, TY; Kleshchenko, YY; Schuster, I; Nes, WD; Hill, GC; Villalta, F; Waterman, MR Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth. Chem Biol14:1283-93 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Lanosterol 14-alpha-demethylase |
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| Name: | Lanosterol 14-alpha-demethylase |
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| Synonyms: | Lanosterol 14-alpha demethylase | Sterol 14-alpha demethylase (CYP51) |
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| Type: | Protein |
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| Mol. Mass.: | 54377.77 |
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| Organism: | Trypanosoma brucei |
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| Description: | Q385E8 |
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| Residue: | 481 |
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| Sequence: | MLLEVAIFLLTALALYSFYFVKSFNVTRPTDPPVYPVTVPILGHIIQFGKSPLGFMQECK
RQLKSGIFTINIVGKRVTIVGDPHEHSRFFLPRNEVLSPREVYSFMVPVFGEGVAYAAPY
PRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAANWDKDEGEINLLEDCSTMIINTAC
QCLFGEDLRKRLDARRFAQLLAKMESSLIPAAVFLPILLKLPLPQSARCHEARTELQKIL
SEIIIARKEEEVNKDSSTSDLLSGLLSAVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITT
TWSMLHLMHPANVKHLEALRKEIEEFPAQLNYNNVMDEMPFAERCARESIRRDPPLLMLM
RKVMADVKVGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPERDEKVEGAFIGFGAGVH
KCIGQKFGLLQVKTILATAFRSYDFQLLRDEVPDPDYHTMVVGPTASQCRVKYIRRKAAA
A
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| BDBM81310 |
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| n/a |
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| Name | BDBM81310 |
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| Synonyms: | Azole, 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15Cl2N5O2 |
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| Mol. Mass. | 428.271 |
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| SMILES | Clc1ccc(C(Cn2ccnc2)NC(=O)c2nnc(o2)-c2ccccc2)c(Cl)c1 |
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| Structure | 
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