Reaction Details |
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Target | Sterol 14-alpha demethylase |
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Ligand | BDBM81309 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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pH | 6±0 |
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Kd | 1.1e+2±n/a nM |
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Citation | Lepesheva, GI; Ott, RD; Hargrove, TY; Kleshchenko, YY; Schuster, I; Nes, WD; Hill, GC; Villalta, F; Waterman, MR Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth. Chem Biol14:1283-93 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Sterol 14-alpha demethylase |
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Name: | Sterol 14-alpha demethylase |
Synonyms: | CP51_TRYCC | CYP51 | Cytochrome P450 51 | Lanosterol 14-alpha demethylase | Sterol 14α-demethylase (CYP51) | Sterol 14-alpha demethylase | Sterol 14-alpha demethylase (CYP51) | Tc14DM |
Type: | Protein |
Mol. Mass.: | 54690.12 |
Organism: | Trypanosoma cruzi |
Description: | Q7Z1V1 |
Residue: | 481 |
Sequence: | MFIEAIVLALTALILYSVYSVKSFNTTRPTDPPVYPVTVPFLGHIVQFGKNPLEFMQRCK
RDLKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPY
PRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTAC
QCLFGEDLRKRLNARHFAQLLSKMESSLIPAAVFMPWLLRLPLPQSARCREARAELQKIL
GEIIVAREKEEASKDNNTSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITT
SWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVM
RMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGAFIGFGAGVH
KCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVKYTRKKKLP
S
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BDBM81309 |
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n/a |
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Name | BDBM81309 |
Synonyms: | Azole, 17 |
Type | Small organic molecule |
Emp. Form. | C27H27ClN4O2 |
Mol. Mass. | 474.982 |
SMILES | CCCCOc1ccc(cc1)-c1ccc(cc1)C(=O)NC(Cn1ccnc1)c1ccc(Cl)cn1 |
Structure |
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