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TargetSterol 14-alpha demethylase
LigandBDBM81309
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH6±0
Kd 1.1e+2±n/a nM
Citation Lepesheva, GIOtt, RDHargrove, TYKleshchenko, YYSchuster, INes, WDHill, GCVillalta, FWaterman, MR Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth. Chem Biol14:1283-93 (2007) [PubMed]  Article
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Sterol 14-alpha demethylase
Name:Sterol 14-alpha demethylase
Synonyms:CP51_TRYCC | CYP51 | Cytochrome P450 51 | Lanosterol 14-alpha demethylase | Sterol 14α-demethylase (CYP51) | Sterol 14-alpha demethylase | Sterol 14-alpha demethylase (CYP51) | Tc14DM
Type:Protein
Mol. Mass.:54690.12
Organism:Trypanosoma cruzi
Description:Q7Z1V1
Residue:481
Sequence:
MFIEAIVLALTALILYSVYSVKSFNTTRPTDPPVYPVTVPFLGHIVQFGKNPLEFMQRCK
RDLKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPY
PRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTAC
QCLFGEDLRKRLNARHFAQLLSKMESSLIPAAVFMPWLLRLPLPQSARCREARAELQKIL
GEIIVAREKEEASKDNNTSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITT
SWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVM
RMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGAFIGFGAGVH
KCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVKYTRKKKLP
S
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BDBM81309
n/a
NameBDBM81309
Synonyms:Azole, 17
TypeSmall organic molecule
Emp. Form.C27H27ClN4O2
Mol. Mass.474.982
SMILESCCCCOc1ccc(cc1)-c1ccc(cc1)C(=O)NC(Cn1ccnc1)c1ccc(Cl)cn1
Structure
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