| Reaction Details |
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 | Report a problem with these data |
| Target | Chitotriosidase-1 |
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| Ligand | BDBM10853 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 5.5±0 |
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| IC50 | 4.5e+3±0 nM |
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| Citation |  Andersen, OA; Nathubhai, A; Dixon, MJ; Eggleston, IM; van Aalten, DM Structure-based dissection of the natural product cyclopentapeptide chitinase inhibitor argifin. Chem Biol15:295-301 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Chitotriosidase-1 |
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| Name: | Chitotriosidase-1 |
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| Synonyms: | CHIT1 | CHIT1_HUMAN | Chitinase 1 | Chitinase-1 | Chitotriosidase | Chitotriosidase-1 | Chitotriosidase-1 (CHIT1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 51682.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13231 |
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| Residue: | 466 |
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| Sequence: | MVRSVAWAGFMVLLMIPWGSAAKLVCYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAG
MTNHQLSTTEWNDETLYQEFNGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFV
NSAIRFLRKYSFDGLDLDWEYPGSQGSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLL
SAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSWEKVTGHNSPLYKRQEESGAAAS
LNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDTRVGAPATGSGTPGPFTKEGGM
LAYYEVCSWKGATKQRIQDQKVPYIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWAL
DLDDFAGFSCNQGRYPLIQTLRQELSLPYLPSGTPELEVPKPGQPSEPEHGPSPGQDTFC
QGKADGLYPNPRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTWN
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| BDBM10853 |
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| n/a |
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| Name | BDBM10853 |
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| Synonyms: | (2R,5S,8S,11S,15S)-8-benzyl-2,7-dimethyl-5-[3-({[(methylcarbamoyl)amino]methanimidoyl}amino)propyl]-3,6,9,13,17-pentaoxo-1,4,7,10,14-pentaazacycloheptadecane-11,15-dicarboxylic acid | Argifin |
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| Type | Small organic molecule |
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| Emp. Form. | C29H41N9O10 |
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| Mol. Mass. | 675.6901 |
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| SMILES | CNC(=O)NC(=N)NCCC[C@@H]1NC(=O)[C@@H](C)NC(=O)C[C@H](NC(=O)C[C@H](NC(=O)[C@H](Cc2ccccc2)N(C)C1=O)C(O)=O)C(O)=O |r| |
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| Structure | 
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