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TargetPutative farnesyl pyrophosphate synthase
LigandBDBM12576
Substrate/Competitorn/a
Meas. Tech.Enzymatic Assay
pH7.7±0
Temperature310.15±0 K
Ki 0.38±0.12 nM
IC50 45.7±2.6 nM
Citation Artz, JDDunford, JEArrowood, MJDong, AChruszcz, MKavanagh, KLMinor, WRussell, RGEbetino, FHOppermann, UHui, R Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis. Chem Biol15:1296-306 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Putative farnesyl pyrophosphate synthase
Name:Putative farnesyl pyrophosphate synthase
Synonyms:n/a
Type:Enzyme
Mol. Mass.:44960.82
Organism:Cryptosporidium parvum
Description:Belongs to the FPP/GGPP synthase family. Q5CR09
Residue:384
Sequence:
ILFHLLKITFIDSIFFALHDNYLTPQFIFNKMNDLQIEYDYTDFINYYDKFKVIVYNVLK
KLPLNDEIRKPVIEYYLNCIDYNVKKGKHIRGKILVLISSLSSAYSNIKRDSIYLLGWVV
EAIQALILIADDIMDSGKFRRGAPCWYIVHGQSNAINDIFFLKMLSLSLIFELSSVFGND
IVMKIQKIYNESIFFTVLGQHLDLSYFDLSKADKISERYFSMVEMKTSRYTFYMPVFFGL
TLSEIQVSSAQLNLIEAILYKLGEFYQVHNDVSDYLFNDSNADDICRFKLTWPLQKSFEI
ADEEMKLKISENYGKNSSLVKDCYNLLKINEHYLEYQRNALDYLIKLVKDITDDSLQKVF
IHLIHQISELITNSRSNADSNNSL
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  Blast E-value cutoff:
BDBM12576
n/a
NameBDBM12576
Synonyms:Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound 64 | RIS | Risdronate | US11279719, Example Risedronic acid RIS | [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonic acid
TypeSmall organic molecule
Emp. Form.C7H11NO7P2
Mol. Mass.283.1123
SMILESOC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O
Structure
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