Reaction Details |
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Target | Putative farnesyl pyrophosphate synthase |
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Ligand | BDBM12578 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Enzymatic Assay |
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pH | 7.7±0 |
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Temperature | 310.15±0 K |
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Ki | 0.050±0.038 nM |
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IC50 | 30.1±1.1 nM |
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Citation | Artz, JD; Dunford, JE; Arrowood, MJ; Dong, A; Chruszcz, M; Kavanagh, KL; Minor, W; Russell, RG; Ebetino, FH; Oppermann, U; Hui, R Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis. Chem Biol15:1296-306 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Putative farnesyl pyrophosphate synthase |
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Name: | Putative farnesyl pyrophosphate synthase |
Synonyms: | n/a |
Type: | Enzyme |
Mol. Mass.: | 44960.82 |
Organism: | Cryptosporidium parvum |
Description: | Belongs to the FPP/GGPP synthase family. Q5CR09 |
Residue: | 384 |
Sequence: | ILFHLLKITFIDSIFFALHDNYLTPQFIFNKMNDLQIEYDYTDFINYYDKFKVIVYNVLK
KLPLNDEIRKPVIEYYLNCIDYNVKKGKHIRGKILVLISSLSSAYSNIKRDSIYLLGWVV
EAIQALILIADDIMDSGKFRRGAPCWYIVHGQSNAINDIFFLKMLSLSLIFELSSVFGND
IVMKIQKIYNESIFFTVLGQHLDLSYFDLSKADKISERYFSMVEMKTSRYTFYMPVFFGL
TLSEIQVSSAQLNLIEAILYKLGEFYQVHNDVSDYLFNDSNADDICRFKLTWPLQKSFEI
ADEEMKLKISENYGKNSSLVKDCYNLLKINEHYLEYQRNALDYLIKLVKDITDDSLQKVF
IHLIHQISELITNSRSNADSNNSL
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BDBM12578 |
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n/a |
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Name | BDBM12578 |
Synonyms: | 2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid | Bisphosphonate 3 | CGP-42446 | CHEMBL924 | JMC515594 Compound 55 | Reclast | US11279719, Example Zolendronic acid (ZOL) | ZOL | Zoledronate | Zometa | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl]phosphonic acid | zoledronic acid |
Type | Small organic molecule |
Emp. Form. | C5H10N2O7P2 |
Mol. Mass. | 272.0896 |
SMILES | OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O |
Structure |
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