| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine aminopeptidase 2 |
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| Ligand | BDBM17446 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibiton Assay |
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| IC50 | 2.0e+3± 1.0e+3 nM |
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| Citation |  Chen, X; Xie, S; Bhat, S; Kumar, N; Shapiro, TA; Liu, JO Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chem Biol16:193-202 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Methionine aminopeptidase 2 |
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| Name: | Methionine aminopeptidase 2 |
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| Synonyms: | MetAP2 | Methionine aminopeptidase (MetAP2) |
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| Type: | Protein |
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| Mol. Mass.: | 40537.47 |
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| Organism: | Plasmodium falciparum |
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| Description: | Q8TA23 |
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| Residue: | 354 |
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| Sequence: | MIYGKDGKYPVGEILEYNNYNLSGQSLVEKKEREKLSIDYYEDLRKAAECHRQVRKHMQA
FIKPGKKMIDIAQETERKTKELILAEKLKCGWGFPTGCSLNHCAAHYTPNYGDETVLKYD
DVCKLDFGVHVNGYIIDCAFTIAFNEKYDNLIKATQDGTNTGIKEAGIDARMCDIGEAIQ
EAIESYEIELNQKIYPIKAISNLRGHSINKYIIHGGKCVPIVRQKEKNEIMEEGELFAIE
TFASTGKGYVNHENECSHYMRNPEKQFVPIRLNSAKTLLKVINDNFDTLPFCNRWLDDLG
QTRHFMALKTLIDLNIVEPYPPLCDIKNSFTSQMEHTILLRPTCKEVLSRGPDF
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| BDBM17446 |
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| n/a |
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| Name | BDBM17446 |
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| Synonyms: | (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl N-(2-chloroacetyl)carbamate | CHEMBL424278 | TNP-470 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H28ClNO6 |
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| Mol. Mass. | 401.882 |
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| SMILES | [H][C@@]1([#6@H](-[#8]-[#6])-[#6@@H](-[#6]-[#6][C@]11[#6]-[#8]1)-[#8]-[#6](=O)-[#7]-[#6](=O)-[#6]Cl)[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r| |
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| Structure | 
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