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TargetMonoglyceride lipase (MGL)
LigandBDBM81363
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
Temperature310.15±0 K
IC50 93±8 nM
Citation King ARDotsey EYLodola AJung KMGhomian AQiu YFu JMor MPiomelli D Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem Biol 16:1045-52 (2009) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Monoglyceride lipase (MGL)
Name:Monoglyceride lipase (MGL)
Synonyms:MAGL | Monoacylglycerol lipase | Monoglyceride lipase
Type:Enzyme
Mol. Mass.:33505.38
Organism:Rattus norvegicus (Rat)
Description:Q8R431
Residue:303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDE
LAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLG
HSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRID
SSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADR
LCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGAR
CLP
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  Blast E-value cutoff:
BDBM81363
n/a
NameBDBM81363
Synonyms:Pristimerin
TypeSmall organic molecule
Emp. Form.C30H40O4
Mol. Mass.464.6362
SMILESCOC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CC=c5c(cc(O)c(O)c5=C)[C@]4(C)CC[C@@]3(C)C2C1 |r,c:16,t:14|
Structure
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