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TargetCyclin-dependent kinase 2
LigandBDBM81432
Substrate/Competitorn/a
Meas. Tech.In Vitro Kinase Assay
Ki 26±3 nM
Citation Wang SGriffiths GMidgley CABarnett ALCooper MGrabarek JIngram LJackson WKontopidis GMcClue SJMcInnes CMcLachlan JMeades CMezna MStuart IThomas MPZheleva DILane DPJackson RCGlover DMBlake DGFischer PM Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents. Chem Biol 17:1111-21 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 2
Name:Cyclin-dependent kinase 2
Synonyms:CDK2 | CDK2-Kinase | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM81432
n/a
NameBDBM81432
Synonyms:CDK Inhibitor, 5
TypeSmall organic molecule
Emp. Form.C15H16N6O2S2
Mol. Mass.376.457
SMILESCNS(=O)(=O)c1cccc(Nc2nccc(n2)-c2sc(N)nc2C)c1
Structure
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