Ki Summary

Reaction Details

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Target

Cyclin-dependent kinase 4

Ligand

BDBM8061

Substrate/Competitor

n/a

Meas. Tech.

In Vitro Kinase Assay

19±17 nM

Citation

Wang, S; Griffiths, G; Midgley, CA; Barnett, AL; Cooper, M; Grabarek, J; Ingram, L; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; McLachlan, J; Meades, C; Mezna, M; Stuart, I; Thomas, MP; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Blake, DG; Fischer, PM Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents. Chem Biol17:1111-21 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cyclin-dependent kinase 4

Name:

Cyclin-dependent kinase 4

Synonyms:

CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3

Type:

Enzyme Subunit

Mol. Mass.:

33731.96

Organism:

Homo sapiens (Human)

Description:

P11802

Residue:

303

Sequence:

MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE

BDBM8061

n/a

Name

BDBM8061

Synonyms:

2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 32 | 4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitrophenyl)pyrimidin-2-amine, 4 | 4-methyl-5-{2-[(3-nitrophenyl)amino]pyrimidin-4-yl}-1,3-thiazol-2-amine | CDK Inhibitor, 1 | [4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl](3-nitrophenyl)amine

Type

Small organic molecule

Emp. Form.

C14H12N6O2S

Mol. Mass.

328.349

SMILES

Cc1nc(N)sc1-c1ccnc(Nc2cccc(c2)N(=O)=O)n1

Structure