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TargetCyclin-dependent kinase 4
LigandBDBM81431
Substrate/Competitorn/a
Meas. Tech.In Vitro Kinase Assay
Ki 20±7 nM
Citation Wang SGriffiths GMidgley CABarnett ALCooper MGrabarek JIngram LJackson WKontopidis GMcClue SJMcInnes CMcLachlan JMeades CMezna MStuart IThomas MPZheleva DILane DPJackson RCGlover DMBlake DGFischer PM Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents. Chem Biol 17:1111-21 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 4
Name:CDK4/CDK9
Synonyms:CDK4 | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:Enzyme Subunit
Mol. Mass.:33731.96
Organism:Homo sapiens (Human)
Description:P11802
Residue:303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM81431
n/a
NameBDBM81431
Synonyms:CDK Inhibitor, 4
TypeSmall organic molecule
Emp. Form.C16H18N6O2S2
Mol. Mass.390.483
SMILESCNc1nc(C)c(s1)-c1ccnc(Nc2cccc(c2)S(=O)(=O)NC)n1
Structure
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