| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase C |
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| Ligand | BDBM81552 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay |
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| IC50 | 41±0.0 nM |
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| Citation |  Miduturu, CV; Deng, X; Kwiatkowski, N; Yang, W; Brault, L; Filippakopoulos, P; Chung, E; Yang, Q; Schwaller, J; Knapp, S; King, RW; Lee, JD; Herrgard, S; Zarrinkar, P; Gray, NS High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem Biol18:868-79 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase C |
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| Name: | Aurora kinase C |
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| Synonyms: | AIE2 | AIK3 | AIRK3 | ARK3 | AURKC | AURKC_HUMAN | Aurora Kinase C (Aurora-C) | Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora-C/INCENP | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | STK13 | Serine/threonine-protein kinase 13 | Serine/threonine-protein kinase Aurora-C |
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| Type: | Enzyme |
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| Mol. Mass.: | 35602.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system. |
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| Residue: | 309 |
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| Sequence: | MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
LPPCAQMAS
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| BDBM81552 |
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| n/a |
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| Name | BDBM81552 |
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| Synonyms: | Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one, 1 | Scaffold, B54 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N6O2 |
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| Mol. Mass. | 430.5022 |
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| SMILES | CN1c2ccccc2C(=O)N(C)c2cnc(Nc3ccc(cc3)N3CCC(O)CC3)nc12 |
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| Structure | 
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