| Reaction Details |
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 | Report a problem with these data |
| Target | Proto-oncogene tyrosine-protein kinase Src |
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| Ligand | BDBM27216 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Inhibition Assay |
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| pH | 7.4±0 |
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| Temperature | 277.15±0 K |
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| IC50 | 2.4e+2±n/a nM |
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| Citation |  Dalgarno, D; Stehle, T; Narula, S; Schelling, P; van Schravendijk, MR; Adams, S; Andrade, L; Keats, J; Ram, M; Jin, L; Grossman, T; MacNeil, I; Metcalf, C; Shakespeare, W; Wang, Y; Keenan, T; Sundaramoorthi, R; Bohacek, R; Weigele, M; Sawyer, T Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds. Chem Biol Drug Des67:46-57 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Proto-oncogene tyrosine-protein kinase Src |
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| Name: | Proto-oncogene tyrosine-protein kinase Src |
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| Synonyms: | Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src |
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| Type: | Protein |
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| Mol. Mass.: | 59838.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P12931 |
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| Residue: | 536 |
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| Sequence: | MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
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| BDBM27216 |
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| n/a |
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| Name | BDBM27216 |
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| Synonyms: | (2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)-3-methylbutan-1-ol | 2,6,9-Trisubstitute purine, 1 | CHEMBL23327 | Purvalanol A |
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| Type | Small organic molecule |
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| Emp. Form. | C19H25ClN6O |
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| Mol. Mass. | 388.894 |
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| SMILES | CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1 |
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| Structure | 
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