| Reaction Details |
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 | Report a problem with these data |
| Target | p53 binding protein |
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| Ligand | BDBM81632 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HDM2 Binding Assay |
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| IC50 | 1.0e+3±n/a nM |
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| Citation |  Cummings, MD; Schubert, C; Parks, DJ; Calvo, RR; LaFrance, LV; Lattanze, J; Milkiewicz, KL; Lu, T Substituted 1,4-benzodiazepine-2,5-diones as alpha-helix mimetic antagonists of the HDM2-p53 protein-protein interaction. Chem Biol Drug Des67:201-5 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| p53 binding protein |
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| Name: | p53 binding protein |
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| Synonyms: | HDM2 | HDM2-HD1 protein | HDM2-p53 protein | P53 binding protein |
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| Type: | Protein |
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| Mol. Mass.: | 10726.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H4C2 |
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| Residue: | 98 |
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| Sequence: | MCNTNMSVPTDGAVTTSQIPASEQETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHG
KTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
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| BDBM81632 |
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| n/a |
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| Name | BDBM81632 |
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| Synonyms: | BZD Scaffold, 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H21Cl2N2O4 |
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| Mol. Mass. | 496.362 |
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| SMILES | CC(C)c1ccc2NC(=O)C(N(C(C([O-])=O)c3ccc(Cl)cc3)C(=O)c2c1)c1ccc(Cl)cc1 |
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| Structure | 
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