Ki Summary

Reaction Details

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Target

Cysteinyl leukotriene receptor 2

Ligand

BDBM50009075

Substrate/Competitor

n/a

6.89±n/a nM

Comments

PDSP_953

Citation

Shirley, JT; Cheng, JB Competition of leukotrienes and ICI-198,615 for [3H]LTD4 binding sites in guinea pig lung membranes suggests the involvement of two LTD4 receptor subtypes. J Pharmacol Exp Ther258:531-6 (1991) [PubMed]

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Cysteinyl leukotriene receptor 2

Name:

Cysteinyl leukotriene receptor 2

Synonyms:

CYSLT2R | Cysltr2 | Leukotriene D4 Beta | Uncharacterized protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

36091.77

Organism:

GUINEA PIG

Description:

Q2NNR4

Residue:

317

Sequence:

MEPNNSSSRNCMIQESFKKEFYPVTYLVIFVWGALGNGLSIYVFLQTYKKSTSANVFMLN
LAMSDLLFISTLPFRAHYYLNNSNWIFGDVPCRIMSYSLYVNMYTSIYFLTVLSVVRFLA
TVHPFRLLHVTSFRSAWILCGIIWIFTMASAAVLLMHGSEPKNSITTCLELDIRKVGKLK
VMNHIALVVGFLLPFFTLSICYLLVIRVLLKVEIPESTLRASHRKALITIIIALITFLLC
FLPYHTLRTLHLITWNKDSCGNGLHKAVVITLALAAANSCVNPFLYYFAGENFKDKLKAV
FIKDHPQKAKCSFPICL

BDBM50009075

n/a

Name

BDBM50009075

Synonyms:

CHEMBL22033 | ICI 198615 | ICI-198615 | [1-(4-Benzenesulfonylaminocarbonyl-2-methoxy-benzyl)-1H-indazol-5-yl]-carbamic acid cyclopentyl ester | [1-(4-Benzenesulfonylaminocarbonyl-2-methoxy-benzyl)-1H-indazol-6-yl]-carbamic acid cyclopentyl ester | [1-(4-Benzenesulfonylaminocarbonyl-2-methoxy-benzyl)-1H-indazol-6-yl]-carbamic acid cyclopentyl ester (ICI 198,615) | [1-(4-Benzenesulfonylaminocarbonyl-2-methoxy-benzyl)-1H-indazol-6-yl]-carbamic acid cyclopentyl ester(ICI 198, 615) | [1-(4-Benzenesulfonylaminocarbonyl-2-methoxy-benzyl)-1H-indazol-6-yl]-carbamic acid cyclopentyl ester(ICI 198615)

Type

Small organic molecule

Emp. Form.

C28H28N4O6S

Mol. Mass.

548.61

SMILES

COc1cc(ccc1Cn1ncc2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1

Structure