| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase A |
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| Ligand | BDBM106152 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Acetyl-Histone Binding Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | >10000±0.0 nM |
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| Comments | extracted |
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| Citation |  Bradner, JE; Gray, NS; Qi, J; McKeown, MR; Buckley, D Diazepane derivatives and uses thereof US Patent US9695172 Publication Date 7/4/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase A |
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| Name: | Aurora kinase A |
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| Synonyms: | AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 45830.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14965 |
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| Residue: | 403 |
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| Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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| BDBM106152 |
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| n/a |
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| Name | BDBM106152 |
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| Synonyms: | US9695172, 2-221 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N5O3S |
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| Mol. Mass. | 409.462 |
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| SMILES | CN1c2ccccc2C(=O)N(C)c2ccc(Nc3ccc(cc3)S(N)(=O)=O)nc12 |
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| Structure | 
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