| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium release-activated calcium channel protein 1 |
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| Ligand | BDBM16173 |
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| Substrate/Competitor | n/a |
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| Ki | >10000±n/a nM |
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| Comments | PDSP_2650 |
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| Citation |  Garritsen, A; Ijzerman, AP; Tulp, MT; Cragoe, EJ; Soudijn, W Receptor binding profiles of amiloride analogues provide no evidence for a link between receptors and the Na+/H+ exchanger, but indicate a common structure on receptor proteins. J Recept Res11:891-907 (1991) [PubMed] Article |
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| More Info.: | Get all data from this article |
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| Calcium release-activated calcium channel protein 1 |
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| Name: | Calcium release-activated calcium channel protein 1 |
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| Synonyms: | CRACM1 | CRCM1_HUMAN | Calcium channel (VER) | Calcium release-activated calcium channel | Calcium release-activated calcium channel protein 1 | ORAI1 | Protein orai-1 | TMEM142A | Transmembrane protein 142A |
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| Type: | Protein |
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| Mol. Mass.: | 32676.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96D31 |
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| Residue: | 301 |
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| Sequence: | MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSY
SEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLL
IAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFST
VIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIAST
TIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHY
A
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| BDBM16173 |
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| n/a |
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| Name | BDBM16173 |
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| Synonyms: | 3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinamide;hydrochloride | 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide | Amiloride | Amipramidin | CHEMBL945 |
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| Type | Small organic molecule |
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| Emp. Form. | C6H8ClN7O |
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| Mol. Mass. | 229.627 |
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| SMILES | NC(=N)NC(=O)c1nc(Cl)c(N)nc1N |
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| Structure | 
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