Reaction Details | |||
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Target | Heat shock protein HSP 90-alpha | ||
Ligand | BDBM81915 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Competition Assay | ||
pH | 7.4±0 | ||
IC50 | 0.2±0.0 nM | ||
Citation | Feldman, RI; Mintzer, B; Zhu, D; Wu, JM; Biroc, SL; Yuan, S; Emayan, K; Chang, Z; Chen, D; Arnaiz, DO; Bryant, J; Ge, XS; Whitlow, M; Adler, M; Polokoff, MA; Li, WW; Ferrer, M; Sato, T; Gu, JM; Shen, J; Tseng, JL; Dinter, H; Buckman, B Potent triazolothione inhibitor of heat-shock protein-90. Chem Biol Drug Des74:43-50 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Heat shock protein HSP 90-alpha | |||
Name: | Heat shock protein HSP 90-alpha | ||
Synonyms: | HS90A_HUMAN | HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat Shock Protein 90 (Hsp90) | Heat shock 86 kDa | Heat shock protein HSP 90 (HSP90) | Heat shock protein HSP 90-alpha (HSP90) | Heat shock protein HSP 90-alpha (HSP90A) | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38 | heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2 | ||
Type: | Molecular Chaperone | ||
Mol. Mass.: | 84623.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P07900 | ||
Residue: | 732 | ||
Sequence: |
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BDBM81915 | |||
n/a | |||
Name | BDBM81915 | ||
Synonyms: | Ethyl analog, 4 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H17N3O2S | ||
Mol. Mass. | 363.433 | ||
SMILES | CCc1cc(-c2n[nH]c(=S)n2-c2cccc3ccccc23)c(O)cc1O |(-.66,2.94,;.68,3.71,;2.01,2.94,;3.35,3.71,;4.68,2.94,;5.88,3.91,;7.36,3.51,;8.2,4.8,;7.23,6,;7.63,7.48,;5.8,5.45,;4.46,6.22,;3.13,5.44,;1.79,6.21,;1.79,7.76,;3.13,8.53,;3.13,10.07,;4.46,10.84,;5.8,10.07,;5.8,8.53,;4.46,7.76,;4.68,1.4,;6.01,.63,;3.35,.63,;2.01,1.4,;.68,.63,)| | ||
Structure |