| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-2A adrenergic receptor |
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| Ligand | BDBM50026636 |
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| Substrate/Competitor | n/a |
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| Ki | 8±n/a nM |
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| Comments | PDSP_1590 |
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| Citation |  Hieble, JP; DeMarinis, RM; Fowler, PJ; Matthews, WD Selective alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor selectivity. J Pharmacol Exp Ther236:90-6 (1986) [PubMed] |
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| More Info.: | Get all data from this article |
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| Alpha-2A adrenergic receptor |
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| Name: | Alpha-2A adrenergic receptor |
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| Synonyms: | ADA2A_CAVPO | ADRA2A | Alpha-2A adrenergic receptor | adrenergic Alpha2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48933.12 |
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| Organism: | GUINEA PIG |
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| Description: | adrenergic Alpha2 0 GUINEA PIG::Q60474 |
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| Residue: | 450 |
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| Sequence: | MGSLQPDSGNASWNGTEGPGGGTRATPYSLQVTVTLVCLVGLLILLTVFGNVLVIIAVFT
SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS
IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISFEKAGGGGQ
QPAEPRCEINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAHAA
APPGGAERRPNGLGLERGVGPGGAEAEPLPTQVNGAPGEPAPAGPRDAEALDLEESSSSE
HAERPPGARRPERGLRAKSKARASQVKPGDSLPRRAPGAAGSGTSGSGPGEERGGGAKAS
RWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSS
LNPVIYTIFNHDFRRAFKKILCRGDRKRIV
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| BDBM50026636 |
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| n/a |
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| Name | BDBM50026636 |
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| Synonyms: | 17alpha-hydroxy-20alpha-yohimban-16beta-carboxylic acid methyl ester | CHEMBL10347 | RAUWOLSCINE HYDROCHLORIDE | alpha-yohimbine | corynanthidine | isoyohimbine | mesoyohimbine | methyl (16beta,17alpha,20alpha)-17-hydroxyyohimban-16-carboxylate | methyl 17alpha-hydroxy-20alpha-yohimban-16beta-carboxylate | rauwolscine |
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| Type | Small organic molecule |
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| Emp. Form. | C21H26N2O3 |
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| Mol. Mass. | 354.4427 |
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| SMILES | COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r| |
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| Structure | 
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