| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM82117 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 41.4±0.0 nM |
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| Citation |  Ma, X; Woon, RS; Ho, PC; Chui, WK Antiproliferative activity against MCF-7 breast cancer cells by diamino-triazaspirodiene antifolates. Chem Biol Drug Des74:322-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 21603.71 |
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| Organism: | Bos taurus (Cattle) |
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| Description: | P00376 |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSS
VYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKF
EVYEKNN
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| BDBM82117 |
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| n/a |
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| Name | BDBM82117 |
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| Synonyms: | 1,3,5-Triazaspiro[5.5]undeca-1,3-diene-2,4-diamine, IIf |
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| Type | Small organic molecule |
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| Emp. Form. | C18H28N6O |
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| Mol. Mass. | 344.4545 |
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| SMILES | CN(CCCON1C(N)=NC(N)=NC11CCCCC1)c1ccccc1 |c:8,11| |
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| Structure | 
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