Ki Summary

Reaction Details

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Target

P2X purinoceptor 3

Ligand

BDBM271518

Substrate/Competitor

n/a

Meas. Tech.

Rat P2X3 Binding Assay in Rat Serum Albumin (HSA)

IC50

11.0±n/a nM

Citation

Kai, H Aminotriazine derivative and pharmaceutical composition comprising the same US Patent US10065941 Publication Date 9/4/2018

More Info.:

Get all data from this article, Assay Method

P2X purinoceptor 3

Name:

P2X purinoceptor 3

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

44397.63

Organism:

RAT

Description:

Purinergic, P2X3 0 RAT::P49654

Residue:

397

Sequence:

MNCISDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGFGRYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPENEEKYRCVSDS
QCGPERFPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVEMPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTDKDIKRCRFHPEKAPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDGVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADHYKARKFEE
VTETTLKGTASTNPVFASDQATVEKQSTDSGAYSIGH

BDBM271518

n/a

Name

BDBM271518

Synonyms:

US10065941, Compound I-019 | US9732060, Compound I-019

Type

Small organic molecule

Emp. Form.

C26H21ClFN5O5

Mol. Mass.

537.927

SMILES

OC(=O)[C@H]1C[C@@H](C1)n1c(=O)[nH]\c(=N/c2ccc(Oc3ccc(F)cn3)cc2)n(Cc2ccc(Cl)cc2)c1=O |r,wU:3.2,wD:5.7,(8.28,1.86,;6.94,2.63,;6.94,4.17,;5.61,1.86,;5.21,.37,;3.72,.77,;4.12,2.26,;2.39,,;1.06,.77,;1.06,2.31,;-.28,,;-.28,-1.54,;-1.61,-2.31,;-2.94,-1.54,;-2.94,,;-4.28,.77,;-5.61,,;-6.94,.77,;-6.94,2.31,;-8.28,3.08,;-8.28,4.62,;-6.94,5.39,;-6.94,6.93,;-5.61,4.62,;-5.61,3.08,;-5.61,-1.54,;-4.28,-2.31,;1.06,-2.31,;1.06,-3.85,;2.39,-4.62,;2.39,-6.16,;3.72,-6.93,;5.06,-6.16,;6.39,-6.93,;5.06,-4.62,;3.72,-3.85,;2.39,-1.54,;3.72,-2.31,)|

Structure