| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbonic anhydrase 6 |
|---|
| Ligand | BDBM13054 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Inhbition Assay |
|---|
| pH | 7.5±0 |
|---|
| Temperature | 293.15±0 K |
|---|
| Ki | 10±0 nM |
|---|
| Citation |  Winum, JY; Montero, JL; Vullo, D; Supuran, CT Carbonic anhydrase inhibitors: glycosylsulfanilamides act as subnanomolar inhibitors of the human secreted isoform VI. Chem Biol Drug Des74:636-9 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Carbonic anhydrase 6 |
|---|
| Name: | Carbonic anhydrase 6 |
|---|
| Synonyms: | CA-VI | CA6 | CAH6_HUMAN | Carbonate dehydratase VI | Carbonic Anhydrase VI | Carbonic anhydrase | Carbonic anhydrase 6 | Carbonic anhydrase 6 (CA VI) | Carbonic anhydrase 6 (CA-VI) | Carbonic anhydrase VI (CA VI) | Salivary carbonic anhydrase | Secreted carbonic anhydrase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 35371.40 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P23280 |
|---|
| Residue: | 308 |
|---|
| Sequence: | MRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPACGGQRQSPINLQRTKVRYN
PSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTVYIAQQMHFHWGGASSE
ISGSEHTVDGIRHVIEIHIVHYNSKYKSYDIAQDAPDGLAVLAAFVEVKNYPENTYYSNF
ISHLANIKYPGQRTTLTGLDVQDMLPRNLQHYYTYHGSLTTPPCTENVHWFVLADFVKLS
RTQVWKLENSLLDHRNKTIHNDYRRTQPLNHRVVESNFPNQEYTLGSEFQFYLHKIEEIL
DYLRRALN
|
|
|
|---|
| BDBM13054 |
|---|
| n/a |
|---|
| Name | BDBM13054 |
|---|
| Synonyms: | (2R,4R)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1,7-thieno[2,3-b]thiopyran-6-sulfonamide | Dorzolamide, DZA | sulfonamide 5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H16N2O4S3 |
|---|
| Mol. Mass. | 324.44 |
|---|
| SMILES | CCN[C@@H]1C[C@@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
