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TargetEndoplasmic reticulum chaperone BiP
LigandBDBM82129
Substrate/Competitorn/a
Meas. Tech.SPR assay
pH7.4±0
Temperature298.15±0 K
Kd 2.41e+3±n/a nM
KOFF 0.4 s-1
Citation Macias, ATWilliamson, DSAllen, NBorgognoni, JClay, ADaniels, ZDokurno, PDrysdale, MJFrancis, GLGraham, CJHowes, RMatassova, NMurray, JBParsons, RShaw, TSurgenor, AETerry, LWang, YWood, MMassey, AJ Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity. J Med Chem54:4034-41 (2011) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Endoplasmic reticulum chaperone BiP
Name:Endoplasmic reticulum chaperone BiP
Synonyms:3.6.4.10 | 78 kDa glucose-regulated protein | BIP_HUMAN | BiP | Binding-immunoglobulin protein | Endoplasmic reticulum chaperone BiP | Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 | GRP-78 | GRP78 | HSP70 family protein 5 | HSPA5 | Heat shock 70 kDa protein 5 | Heat shock protein 70 family protein 5 | Heat shock protein family A member 5 | Immunoglobulin heavy chain-binding protein | Synonyms=GRP78
Type:n/a
Mol. Mass.:72312.92
Organism:Homo sapiens (Human)
Description:P11021
Residue:654
Sequence:
MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNR
ITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVV
EKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQ
RQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNG
VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALS
SQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIV
LVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVC
PLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLG
TFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIER
MVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEE
KIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL
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  Blast E-value cutoff:
BDBM82129
n/a
NameBDBM82129
Synonyms:(2R,3R,4S,5R)-2-{6-Amino-8-[(quinolin-2-ylmethyl)amino]- purin-9-yl}-5-hydroxymethyltetrahydrofuran-3,4-diol | adenosine-derived inhibitor (Grp78), 10
TypeSmall organic molecule
Emp. Form.C20H21N7O4
Mol. Mass.423.4252
SMILESNc1ncnc2n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c(NCc3ccc4ccccc4n3)nc12 |r|
Structure
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