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TargetHeat Shock 70kDa Protein 1
LigandBDBM82124
Substrate/Competitorn/a
Meas. Tech.Fluorescence-Polarization (FP) Binding Assay
pH7.4±0
Temperature298.15±0 K
Ki 1.1e+2± 0 nM
Citation Macias ATWilliamson DSAllen NBorgognoni JClay ADaniels ZDokurno PDrysdale MJFrancis GLGraham CJHowes RMatassova NMurray JBParsons RShaw TSurgenor AETerry LWang YWood MMassey AJ Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity. J Med Chem 54:4034-41 (2011) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Heat Shock 70kDa Protein 1
Name:Heat Shock 70kDa Protein 1
Synonyms:HSP70-1/HSP70-2 | HSP70.1 | Hsp70
Type:Chaperone
Mol. Mass.:70043.82
Organism:Homo sapiens (Human)
Description:n/a
Residue:641
Sequence:
MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVA
LNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEIS
SMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAA
IAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNH
FVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRA
RFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLN
KSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTI
PTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDI
DANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKN
ALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELE
QVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM82124
n/a
NameBDBM82124
Synonyms:adenosine-derived inhibitor (Grp78), 1
TypeSmall organic molecule
Emp. Form.C10H14N5O10P2
Mol. Mass.426.1937
SMILESNc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)([O-])=O)[C@@H](O)[C@H]1O |r|
Structure
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